Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature

Title: Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature

Volume: 2 Issue: 5

Author(s): M. Zahouily, A. Elmakssoudi, A. Mezdar, A. Rayadh, S. Sebti and H. B. Lazrek

Affiliation:

Keywords: synthetic phosphate, amino phosphonates, heterogeneous catalysis, recyclable catalyst

Abstract: Synthetic phosphate Na2CaP2O7 has been utilized as an efficient catalyst for the three components coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphite to produce α-amino phosphonates. The reaction was carried out under solvent-free conditions at room temperature. The by-product H2O formed during the reaction increases the catalytic activity of Na2CaP2O7.

Cite this article as:

Zahouily M., Elmakssoudi A., Mezdar A., Rayadh A., Sebti S. and Lazrek B. H., Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature, Letters in Organic Chemistry 2005; 2 (5) . https://dx.doi.org/10.2174/1570178054405887