Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

Title: Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

Volume: 2 Issue: 7

Author(s): D. Belotti, J. L. Peglion and J. Cossy

Affiliation:

Keywords: kinase inhibitor, rho-associated kinase, reductive amination

Abstract: Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone.

Cite this article as:

Belotti D., Peglion L. J. and Cossy J., Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer, Letters in Organic Chemistry 2005; 2 (7) . https://dx.doi.org/10.2174/157017805774297019