One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

H.      El Badaoui; F.      Bazi; S.      Sokori; S.      Boulaajaj; H.   B.   Lazrek; S.      Sebti

doi:10.2174/1570178054640750

Abstract

Hydroxyapatite doped with ZnCl2, CuCl2, NiCl2 and CoCl2 efficiently catalyses the three components Biginelli reaction between an aldehyde, ethyl acetoacetate and urea in refluxing toluene to afford the corresponding dihydropyrimidinones in high yields.

Keywords: biginelli reaction, heterogeneous catalysis, dihydropyrimidinones, hydroxyapatite, lewis acids

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Letters in Organic Chemistry

Title: One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

Volume: 2 Issue: 6

Author(s): H. El Badaoui, F. Bazi, S. Sokori, S. Boulaajaj, H. B. Lazrek and S. Sebti

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Keywords: biginelli reaction, heterogeneous catalysis, dihydropyrimidinones, hydroxyapatite, lewis acids

Abstract: Hydroxyapatite doped with ZnCl2, CuCl2, NiCl2 and CoCl2 efficiently catalyses the three components Biginelli reaction between an aldehyde, ethyl acetoacetate and urea in refluxing toluene to afford the corresponding dihydropyrimidinones in high yields.

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El Badaoui H., Bazi F., Sokori S., Boulaajaj S., Lazrek B. H. and Sebti S., One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite, Letters in Organic Chemistry 2005; 2 (6) . https://dx.doi.org/10.2174/1570178054640750