Efficient Chemical Synthesis of Sialic Acid Related Oligosaccharides

C.      Zhao; X.      Zhen; H.      Zhang; Y.      Ding

doi:10.2174/1570178054640732

Abstract

A very efficient strategy for the chemical synthesis of the sialyl Lewis X tetrasaccharide is reported. Starting from four simple monosaccharide building blocks, sialyl Lewis X was obtained in seven steps. By using similar strategy, sialyl LacNAc and sulfated sialyl LacNAc trisaccharides were also synthesized.

Keywords: tetrasaccharide, inflammation, monosaccharide, sialylation, hydrogenation

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Letters in Organic Chemistry

Title: Efficient Chemical Synthesis of Sialic Acid Related Oligosaccharides

Volume: 2 Issue: 6

Author(s): C. Zhao, X. Zhen, H. Zhang and Y. Ding

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Keywords: tetrasaccharide, inflammation, monosaccharide, sialylation, hydrogenation

Abstract: A very efficient strategy for the chemical synthesis of the sialyl Lewis X tetrasaccharide is reported. Starting from four simple monosaccharide building blocks, sialyl Lewis X was obtained in seven steps. By using similar strategy, sialyl LacNAc and sulfated sialyl LacNAc trisaccharides were also synthesized.

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Zhao C., Zhen X., Zhang H. and Ding Y., Efficient Chemical Synthesis of Sialic Acid Related Oligosaccharides, Letters in Organic Chemistry 2005; 2 (6) . https://dx.doi.org/10.2174/1570178054640732