High Pressure Studies on Transthyretin

Debora      Foguel

doi:10.2174/0929866053587200

Abstract

High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.

Keywords: high hydrostatic pressure, amyloidogenic diseases, protein folding, protein aggregation, transthyretin

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Protein & Peptide Letters

Title: High Pressure Studies on Transthyretin

Volume: 12 Issue: 3

Author(s): Debora Foguel

Affiliation:

Keywords: high hydrostatic pressure, amyloidogenic diseases, protein folding, protein aggregation, transthyretin

Abstract: High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.