Thermodynamic Interpretation of Protein Dynamics from NMR Relaxation Measurements

Leo      Spyracopoulos

doi:10.2174/0929866053587075

Abstract

Protein dynamics and thermodynamics can be characterized through measurements of relaxation rates of side chain 2H and 13C, and backbone 15N nuclei using NMR spectroscopy. The rates reflect protein motions on timescales from picoseconds to milliseconds. Backbone and methyl side chain NMR relaxation measurements for several proteins are beginning to reveal the role of protein dynamics in protein stability and ligand binding.

Keywords: protein backbone and side chain dynamics, thermodynamics, nmr spin relaxation

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Protein & Peptide Letters

Title: Thermodynamic Interpretation of Protein Dynamics from NMR Relaxation Measurements

Volume: 12 Issue: 3

Author(s): Leo Spyracopoulos

Affiliation:

Keywords: protein backbone and side chain dynamics, thermodynamics, nmr spin relaxation

Abstract: Protein dynamics and thermodynamics can be characterized through measurements of relaxation rates of side chain 2H and 13C, and backbone 15N nuclei using NMR spectroscopy. The rates reflect protein motions on timescales from picoseconds to milliseconds. Backbone and methyl side chain NMR relaxation measurements for several proteins are beginning to reveal the role of protein dynamics in protein stability and ligand binding.

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Spyracopoulos Leo, Thermodynamic Interpretation of Protein Dynamics from NMR Relaxation Measurements, Protein & Peptide Letters 2005; 12 (3) . https://dx.doi.org/10.2174/0929866053587075