Abstract
This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.
Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal
Current Topics in Medicinal Chemistry
Title: Recent Advances in the Synthesis of C-oligosaccharides
Volume: 5 Issue: 14
Author(s): Xuejun Yuan and Robert J. Linhardt
Affiliation:
Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal
Abstract: This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.
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Cite this article as:
Yuan Xuejun and Linhardt J. Robert, Recent Advances in the Synthesis of C-oligosaccharides, Current Topics in Medicinal Chemistry 2005; 5 (14) . https://dx.doi.org/10.2174/156802605774643033
DOI https://dx.doi.org/10.2174/156802605774643033 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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