Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †

Title: Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †

Volume: 2 Issue: 4

Author(s): Manojit Pal, Venugopal Rao Veeramaneni, Sanjeev Kumar, Akhila Vangoori, Ramesh Mullangi, Parimal Misra, Shaikh Abdul Rajjak, Vidya B. Lohray, Seshagiri Rao Casturi and Koteswar Rao Yeleswarapu

Affiliation:

Keywords: diarylpyrazoles, cox, &, cox inhibition, structure activity relationship (sar) study

Abstract: A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3- dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. Structure Activity Relationship study within the series are discussed.

Cite this article as:

Pal Manojit, Veeramaneni Rao Venugopal, Kumar Sanjeev, Vangoori Akhila, Mullangi Ramesh, Misra Parimal, Rajjak Abdul Shaikh, Lohray B. Vidya, Casturi Rao Seshagiri and Yeleswarapu Rao Koteswar, Synthesis and Cyclooxygenase-2 (COX-2) Inhibiting Properties of 1,5- Diarylpyrazoles Possessing N-Substitution on the Sulfonamide (-SO2NH2) Moiety †, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038459