A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

S.   P.   Gupta; Anitha      Paleti; S.   B.   Mekapati; A.   N.   Nagappa; S.      Kumaran

doi:10.2174/1570180054038422

Abstract

A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

Keywords: channel blockers, qsar, connectivity index

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Letters in Drug Design & Discovery

Title: A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Volume: 2 Issue: 4

Author(s): S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa and S. Kumaran

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Keywords: channel blockers, qsar, connectivity index

Abstract: A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

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Gupta P. S., Paleti Anitha, Mekapati B. S., Nagappa N. A. and Kumaran S., A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038422