Abstract
Blocking the effects of fractalkine therapeutically may regulate microglia cell activation and provide neuroprotection in the AD brain. A human herpesvirus 8-encoded chemokine, termed vMIP-II is a non-selective chemokine receptor antagonist (binding multiple chemokine receptors, including CX3CR1). By comparing vMIP-II and FKN, we have generated molecules that selectively antagonize CX3CR1 activation. The results from these studies will guide future development of therapeutic agents designed to modulate microglial activation with the goal of preventing or slowing the progression of AD.
Keywords: neuroinflammation, alzheimer, ’, s disease, cns, leukocytes, amyloid-beta (ab) protein, chemokines, g-protein coupled receptors, fkn receptor
Current Alzheimer Research
Title: Role of Fractalkine (CX3CL1) in Regulating Neuron-Microglia Interactions: Development of Viral-Based CX3CR1 Antagonists
Volume: 2 Issue: 2
Author(s): Wolfgang J. Streit, Christopher N. Davis and Jeffrey K. Harrison
Affiliation:
Keywords: neuroinflammation, alzheimer, ’, s disease, cns, leukocytes, amyloid-beta (ab) protein, chemokines, g-protein coupled receptors, fkn receptor
Abstract: Blocking the effects of fractalkine therapeutically may regulate microglia cell activation and provide neuroprotection in the AD brain. A human herpesvirus 8-encoded chemokine, termed vMIP-II is a non-selective chemokine receptor antagonist (binding multiple chemokine receptors, including CX3CR1). By comparing vMIP-II and FKN, we have generated molecules that selectively antagonize CX3CR1 activation. The results from these studies will guide future development of therapeutic agents designed to modulate microglial activation with the goal of preventing or slowing the progression of AD.
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Streit J. Wolfgang, Davis N. Christopher and Harrison K. Jeffrey, Role of Fractalkine (CX3CL1) in Regulating Neuron-Microglia Interactions: Development of Viral-Based CX3CR1 Antagonists, Current Alzheimer Research 2005; 2 (2) . https://dx.doi.org/10.2174/1567205053585765
DOI https://dx.doi.org/10.2174/1567205053585765 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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