Design of Selective Inhibitors of Tyrosine Kinase 2

Title: Design of Selective Inhibitors of Tyrosine Kinase 2

Volume: 2 Issue: 7

Author(s): Kristin Tondel and Finn Drablos

Affiliation:

Keywords: Tyrosine kinase, Protein Alpha Shape Similarity Analysis (PASSA), Protein Alpha Shape (PAS) Dock, inhibitor design, selectivity, database screening

Abstract: Selective inhibitors of tyrosine kinase 2 (Tyk2) were searched for using database screening, de novo ligand design and computational docking in Tyk2 and seven other protein kinases. None of the structures in the National Cancer Institute database seem to inhibit Tyk2 selectively, but five of the designed structures seem promising.

Cite this article as:

Tondel Kristin and Drablos Finn, Design of Selective Inhibitors of Tyrosine Kinase 2, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479104

DOI https://dx.doi.org/10.2174/157018005774479104	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X