Design of Selective Inhibitors of Tyrosine Kinase 2

Kristin      Tondel; Finn      Drablos

doi:10.2174/157018005774479104

Abstract

Selective inhibitors of tyrosine kinase 2 (Tyk2) were searched for using database screening, de novo ligand design and computational docking in Tyk2 and seven other protein kinases. None of the structures in the National Cancer Institute database seem to inhibit Tyk2 selectively, but five of the designed structures seem promising.

Keywords: Tyrosine kinase, Protein Alpha Shape Similarity Analysis (PASSA), Protein Alpha Shape (PAS) Dock, inhibitor design, selectivity, database screening

« Previous Next »

Rights & Permissions Print Cite

Letters in Drug Design & Discovery

Title: Design of Selective Inhibitors of Tyrosine Kinase 2

Volume: 2 Issue: 7

Author(s): Kristin Tondel and Finn Drablos

Affiliation:

Keywords: Tyrosine kinase, Protein Alpha Shape Similarity Analysis (PASSA), Protein Alpha Shape (PAS) Dock, inhibitor design, selectivity, database screening

Abstract: Selective inhibitors of tyrosine kinase 2 (Tyk2) were searched for using database screening, de novo ligand design and computational docking in Tyk2 and seven other protein kinases. None of the structures in the National Cancer Institute database seem to inhibit Tyk2 selectively, but five of the designed structures seem promising.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Tondel Kristin and Drablos Finn, Design of Selective Inhibitors of Tyrosine Kinase 2, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479104