Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships

Title: Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships

Volume: 12 Issue: 1

Author(s): Sarah R. Dennison, James Wallace, Frederick Harris and David A. Phoenix

Affiliation:

Keywords: antimicrobial peptides, amphiphilicity, microbial membranes

Abstract: To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

Cite this article as:

Dennison R. Sarah, Wallace James, Harris Frederick and Phoenix A. David, Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships, Protein & Peptide Letters 2005; 12 (1) . https://dx.doi.org/10.2174/0929866053406084

DOI https://dx.doi.org/10.2174/0929866053406084	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305