Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues

Title: Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues

Volume: 5 Issue: 1

Author(s): W.- S. Fang and X.- T. Liang

Affiliation:

Keywords: anticancer drugs, paclitaxel, structure-activity relationship (sar), multi-drug resistance (mdr), prodrugs, microtubule, pharmacophore

Abstract: Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward “normal” and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.

Cite this article as:

Fang S. W.- and Liang T. X.-, Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues, Mini-Reviews in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1389557053402837