Abstract
Recent developments of the metathesis reaction in the area of biologically active molecules are presented. Scope and limitations of ring-closing metathesis to form medium and large rings are discussed and illustrated by the epothilone synthesis. Applications of the metathesis reaction related to medicinal chemistry, including solid phase synthesis and combinatorial chemistry are presented.
Keywords: epothilone 490, combinatorial chemistry, 1,2,3,6-tetrahydropyridine, ring-closing metathesis, Type I cyclization, molybdenum-derived Schrock catalyst, proteolytic degradation
Current Topics in Medicinal Chemistry
Title: The Application of Olefin Metathesis to the Synthesis of Biologically Active Macrocyclic Agents
Volume: 5 Issue: 15
Author(s): Pierre V. de Weghe and Jacques Eustache
Affiliation:
Keywords: epothilone 490, combinatorial chemistry, 1,2,3,6-tetrahydropyridine, ring-closing metathesis, Type I cyclization, molybdenum-derived Schrock catalyst, proteolytic degradation
Abstract: Recent developments of the metathesis reaction in the area of biologically active molecules are presented. Scope and limitations of ring-closing metathesis to form medium and large rings are discussed and illustrated by the epothilone synthesis. Applications of the metathesis reaction related to medicinal chemistry, including solid phase synthesis and combinatorial chemistry are presented.
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Cite this article as:
de Weghe V. Pierre and Eustache Jacques, The Application of Olefin Metathesis to the Synthesis of Biologically Active Macrocyclic Agents, Current Topics in Medicinal Chemistry 2005; 5 (15) . https://dx.doi.org/10.2174/156802605775009748
DOI https://dx.doi.org/10.2174/156802605775009748 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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