The Impact of Lipophilicity in Drug Research: A Case Report on ß-Blockers

Raimund      Mannhold

doi:10.2174/1389557053402701

Abstract

The key importance of lipophilicity in bio-studies is discussed for ß-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of ß-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant ß-blockers are presented for the first time in this review.

Keywords: blockers, pharmacokinetic, pharmacodynamic and clinical properties, lipophilicity, logp calculation programs, logp compilation for ß-blockers

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Mini-Reviews in Medicinal Chemistry

Title: The Impact of Lipophilicity in Drug Research: A Case Report on ß-Blockers

Volume: 5 Issue: 2

Author(s): Raimund Mannhold

Affiliation:

Keywords: blockers, pharmacokinetic, pharmacodynamic and clinical properties, lipophilicity, logp calculation programs, logp compilation for ß-blockers

Abstract: The key importance of lipophilicity in bio-studies is discussed for ß-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of ß-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant ß-blockers are presented for the first time in this review.

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Mannhold Raimund, The Impact of Lipophilicity in Drug Research: A Case Report on ß-Blockers, Mini-Reviews in Medicinal Chemistry 2005; 5 (2) . https://dx.doi.org/10.2174/1389557053402701