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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Advances in Prodrug Design

Author(s): Antonio Tavora de Albuquerque Silva, Man C. Chung, Lucia F. Castro, Rafael V. Carvalho Guido and Elizabeth I. Ferreira

Volume 5, Issue 10, 2005

Page: [893 - 914] Pages: 22

DOI: 10.2174/138955705774329528

Price: $65

Abstract

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene- Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

Keywords: prodrug design, latent advanced systems, macromolecules carriers, selective delivery systems


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