Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens

N.      Suree; M.   E.   Jung; R.   T.   Clubb

doi:10.2174/138955707782110097

Abstract

Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.

Keywords: Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA

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Mini-Reviews in Medicinal Chemistry

Title: Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens

Volume: 7 Issue: 10

Author(s): N. Suree, M. E. Jung and R. T. Clubb

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Keywords: Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA

Abstract: Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.

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Suree N., Jung E. M. and Clubb T. R., Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens, Mini-Reviews in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/138955707782110097