One-Pot Regioselective Green Synthesis of Novel Quinolines Using a Neat Reaction Technology

Mazaahir      Kidwai; Vikas      Bansal

doi:10.2174/157017807782006263

Abstract

A convenient eco-friendly procedure has been developed for the synthesis of novel quinoline derivatives by a simple one-pot reaction of substituted anilines with β-ketoesters under microwave irradiation without any solvent. A comparative study of reaction on solid support versus neat reaction is done. Neat reaction technology gives better yield in shorter reaction times and also cuts down the usage of solvent.

Keywords: Quinolines, regioselective, microwaves, green chemistry, solid support and neat reaction

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Letters in Organic Chemistry

Title: One-Pot Regioselective Green Synthesis of Novel Quinolines Using a Neat Reaction Technology

Volume: 4 Issue: 7

Author(s): Mazaahir Kidwai and Vikas Bansal

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Keywords: Quinolines, regioselective, microwaves, green chemistry, solid support and neat reaction

Abstract: A convenient eco-friendly procedure has been developed for the synthesis of novel quinoline derivatives by a simple one-pot reaction of substituted anilines with β-ketoesters under microwave irradiation without any solvent. A comparative study of reaction on solid support versus neat reaction is done. Neat reaction technology gives better yield in shorter reaction times and also cuts down the usage of solvent.

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Kidwai Mazaahir and Bansal Vikas, One-Pot Regioselective Green Synthesis of Novel Quinolines Using a Neat Reaction Technology, Letters in Organic Chemistry 2007; 4 (7) . https://dx.doi.org/10.2174/157017807782006263