Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α)

Title: Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α)

Volume: 4 Issue: 7

Author(s): Caroline P. Owen, Sachin Dhanani, Chirag H. Patel and Sabbir Ahmed

Affiliation:

Keywords: 17α-hydroxylase, 17,20-lyase, P45017α, Synthesis, Evaluation, Triazole

Abstract: We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P45017α, in particular, lyase.

Cite this article as:

Owen P. Caroline, Dhanani Sachin, Patel H. Chirag and Ahmed Sabbir, Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α), Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788471