The Potential of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligands in the Treatment of Hematological Malignancies

Title: The Potential of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligands in the Treatment of Hematological Malignancies

Volume: 7 Issue: 9

Author(s): C. Ulivieri and C. T. Baldari

Affiliation:

Keywords: PPARγ ligands, cancer, immune system, cell cycle, apoptosis, TZDs, myeloid neoplasms, lymphoid neoplasms

Abstract: PPARγ has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands. Here we shall review the activities of PPARγ ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies.

Cite this article as:

Ulivieri C. and Baldari T. C., The Potential of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligands in the Treatment of Hematological Malignancies, Mini-Reviews in Medicinal Chemistry 2007; 7 (9) . https://dx.doi.org/10.2174/138955707781662618