Abstract
Data of this study showed that αD-αE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.
Keywords: HSC70, Mutagenesis, Oligomerization, Ultracentrifugation, ATPase activity