Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides

Title: Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides

Volume: 14 Issue: 7

Author(s): Yasser H.A. Abdel-Wahab, Lamin Marenah, Peter R Flatt and J. Michael Conlon

Affiliation:

Keywords: Amphibian skin, insulin secretion, temporin, cytolysis

Abstract: Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10-8 - 10-6M) produced significant (p < 0.05) and concentrationdependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10-8 - 10-6M) also stimulated insulin-release but were cytotoxic at 10-6M. Temporin-1DRa was without effect. The temporins at 10-7 M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a KATP channel- independent pathway.

Cite this article as:

Yasser H.A. Abdel-Wahab , Lamin Marenah , Peter R Flatt and J. Michael Conlon , Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides, Protein & Peptide Letters 2007; 14 (7) . https://dx.doi.org/10.2174/092986607781483822