Abstract
This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.
Keywords: Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis
Mini-Reviews in Medicinal Chemistry
Title: Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors
Volume: 7 Issue: 7
Author(s): Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki, Seiichiro Ogawa, Miki Kanto and Yoshiyuki Suzuki
Affiliation:
Keywords: Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis
Abstract: This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.
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Cite this article as:
Seiichiro Ogawa , Miki Kanto , Yoshiyuki Suzuki , Ogawa Seiichiro, Kanto Miki and Suzuki Yoshiyuki, Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors, Mini-Reviews in Medicinal Chemistry 2007; 7 (7) . https://dx.doi.org/10.2174/138955707781024508
DOI https://dx.doi.org/10.2174/138955707781024508 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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