Development of a Mimotope-Based Vaccine Against CD20 Antigen

Title: Development of a Mimotope-Based Vaccine Against CD20 Antigen

Volume: 14 Issue: 6

Author(s): Meng Li, Wei Han, Quiyang Zhang, Xiaochang Xue, Zenglu Wang and Yingqi Zhang

Affiliation:

Keywords: CD20, mimotope, vaccine, B-cell lymphoma, immunotherapy, keyhole limpet hemocyanin (KLH)

Abstract: CD20, a B-cell-specific protein, is a primary target for immunotherapy of B-cell lymphomas. We used a mimotopes of CD20 to construct vaccines for B-cell-related disorders. The immunogenicity of the vaccines was tested in BALB/c mice. Results of this study suggest that the mimotope may be a useful tool for the construction of a functional vaccine to treat B cell-related disorders.

Cite this article as:

Meng Li , Wei Han , Quiyang Zhang , Xiaochang Xue , Zenglu Wang and Yingqi Zhang , Development of a Mimotope-Based Vaccine Against CD20 Antigen, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989958