Abstract
Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A1 receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.
Keywords: A1-adenosine receptor, allosteric modulators, enhancer, cAMP content, neuroprotection
Mini-Reviews in Medicinal Chemistry
Title: Allosteric Enhancers for A1 Adenosine Receptor
Volume: 7 Issue: 6
Author(s): Pier Giovanni Baraldi, Maria Antonietta Iaconinoto, Allan R. Moorman, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Olga Cruz Lopez, Francesca Fruttarolo, Mojgan Aghazadeh Tabrizi and Romeo Romagnoli
Affiliation:
Keywords: A1-adenosine receptor, allosteric modulators, enhancer, cAMP content, neuroprotection
Abstract: Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A1 receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.
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Pier Giovanni Baraldi , Maria Antonietta Iaconinoto , Allan R. Moorman , Maria Dora Carrion , Carlota Lopez Cara , Delia Preti , Olga Cruz Lopez , Francesca Fruttarolo , Mojgan Aghazadeh Tabrizi and Romeo Romagnoli , Allosteric Enhancers for A1 Adenosine Receptor, Mini-Reviews in Medicinal Chemistry 2007; 7 (6) . https://dx.doi.org/10.2174/138955707780859459
DOI https://dx.doi.org/10.2174/138955707780859459 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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