Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine

Title: Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine

Volume: 4 Issue: 3

Author(s): Peiyuan Jin, Sanhao Ji, Yong Ju and Yufen Zhao

Affiliation:

Keywords: Steroidal conjugate, AZT, phosphate, cytotoxic activity

Abstract: Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3-Azido-3-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.

Cite this article as:

Jin Peiyuan, Ji Sanhao, Ju Yong and Zhao Yufen, Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737336