Smad-Signaling in Mammary Gland Development and Tumorigenesis

Title: Smad-Signaling in Mammary Gland Development and Tumorigenesis

Volume: 2 Issue: 2

Author(s): Vandana Gupta, Arunthathi Thiagalingam and Shyamala Maheswaran

Affiliation:

Keywords: TGFβ, activin, inhibin, BMP, MIS, nodal, cripto-1, smads, breast cancer

Abstract: The Transforming Growth Factor-β (TGFβ) superfamily of cytokines regulates a myriad of cellular processes including proliferation, differentiation and tumorigenesis. Signaling by these growth regulatory molecules is propagated by ligand-induced heterooligomerization of distinct type II and type I serine/threonine kinase receptors, which result in activation of receptor-activated Smad proteins as well as Smad-independent pathways. Disruption of TGFβ induced signaling can contribute to development and progression of human breast cancer. The role of Smad-signaling in mammary gland development and tumorigenesis will be the focus of this review.

Cite this article as:

Gupta Vandana, Thiagalingam Arunthathi and Maheswaran Shyamala, Smad-Signaling in Mammary Gland Development and Tumorigenesis, Current Signal Transduction Therapy 2007; 2 (2) . https://dx.doi.org/10.2174/157436207780619482