New 3-[(4-Hydroxy-6-Methly-2(1H)-Pyridinones)-3-yl]-4-Substituted-(1H)-1,2,4-Triazole-5-Thiones: Efficient Synthesis, X-Ray Crystallographic Analysis, and Antitumor Activity

Title: New 3-[(4-Hydroxy-6-Methly-2(1H)-Pyridinones)-3-yl]-4-Substituted-(1H)-1,2,4-Triazole-5-Thiones: Efficient Synthesis, X-Ray Crystallographic Analysis, and Antitumor Activity

Volume: 4 Issue: 2

Author(s): Jian-Guo Yang and Fu-You Pan

Affiliation:

Keywords: 1,2,4-triazole, antitumor activity, Schiff base, hydroxypyridin-2(1H)-one, biological activity, potential antitumor medicine

Abstract: Fifteen new 3-[(4-hydroxy-6-methly-2(1H)-pyridinones)-3-yl]-4-substituted- (1H)-1,2,4-triazole-5- thione compounds were synthesized from methyl 4-hydroxy-6- methyl-2-oxo-1,2-dihydropyridine-3- carboxylate in good overall yields by four step reactions. Molecular structure of these compounds was confirmed by IR, NMR, MS, elemental analysis and X-ray diffraction. Their antitumor activities were evaluated in vitro by the SRB and MTT methods. The results show that there are two compounds which are highly effective against KB cells and one compound which is highly effective against Bel-7402 cells.

Cite this article as:

Yang Jian-Guo and Pan Fu-You, New 3-[(4-Hydroxy-6-Methly-2(1H)-Pyridinones)-3-yl]-4-Substituted-(1H)-1,2,4-Triazole-5-Thiones: Efficient Synthesis, X-Ray Crystallographic Analysis, and Antitumor Activity, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414181