Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus

Weibo      Cai; Joseph   P.   Taulane; Nohemy   A.   Sorto; Asmik      Oganesyan; Carlos   G.   Gutierrez; Murray      Goodman

doi:10.2174/157017807780414163

Abstract

Here, we report the C-terminal scaffold assembly of triple helical collagen mimetics using a triserine lactone (TSL) scaffold. It was found that the TSL scaffold can promote the triple helix formation and enhance the thermal stability of the resulting collagen-like structures.

Keywords: Scaffold-assembled collagen mimetics, Triserine lactone, Triple helix, Collagen, Circular dichroism, Thermal denaturation

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Letters in Organic Chemistry

Title: Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus

Volume: 4 Issue: 2

Author(s): Weibo Cai, Joseph P. Taulane, Nohemy A. Sorto, Asmik Oganesyan, Carlos G. Gutierrez and Murray Goodman

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Keywords: Scaffold-assembled collagen mimetics, Triserine lactone, Triple helix, Collagen, Circular dichroism, Thermal denaturation

Abstract: Here, we report the C-terminal scaffold assembly of triple helical collagen mimetics using a triserine lactone (TSL) scaffold. It was found that the TSL scaffold can promote the triple helix formation and enhance the thermal stability of the resulting collagen-like structures.

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Cai Weibo, Taulane P. Joseph, Sorto A. Nohemy, Oganesyan Asmik, Gutierrez G. Carlos and Goodman Murray, Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414163