Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing

A.      Bitto; L.      Minutoli; F.      Squadrito; F.      Polito; D.      Altavilla

doi:10.2174/138955707780059835

Abstract

Raxofelast, also named IRFI 016 or (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid, belongs to a family of novel molecules designed with the aim to maximize antioxidant potency of phenols related to Vitamin E ( α-tocopherol). This review will focus on the antioxidant and radical scavenging activity of this new promising compound.

Keywords: Raxofelast, inflammation, ischemia/reperfusion injury, wound healing, diabetes, safety

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