Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

Title: Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

Volume: 4 Issue: 3

Author(s): T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara and O. G. Simonova

Affiliation:

Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels

Abstract: The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.

Cite this article as:

Tolstikova G. T., Bryzgalov O. A., Sorokina V. I., Hvostov V. M., Ratushnyak S. A., Zapara A. T. and Simonova G. O., Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077453