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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

Author(s): Dennis Russowsky, Edilson V. Benvenutti, Gabriela S. Roxo and Fabio Grasel

Volume 4, Issue 1, 2007

Page: [39 - 42] Pages: 4

DOI: 10.2174/157017807780037496

Price: $65

Abstract

The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.

Keywords: Biginelli reaction, dihydropyrimidinones, sol-gel, metal/silica composites, catalysis


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