Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

Title: Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

Volume: 4 Issue: 1

Author(s): Xin Wang, Takami Akagi, Mitsuru Akashi and Masanori Baba

Affiliation:

Keywords: Polystyrene nanoparticles, concanavalin A, HIV-1, mucosal vaccine

Abstract: We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.

Cite this article as:

Wang Xin, Akagi Takami, Akashi Mitsuru and Baba Masanori, Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine, Mini-Reviews in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157019307779815857