myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs

D.   J.   Miller; R.   K.   Allemann

doi:10.2174/138955707779802624

Abstract

myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

Keywords: diacylglycerol, G-protein coupled receptor, Lithitum, myo-Inositol 1-phosphate, Circular dichroism, Zinc ion

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Mini-Reviews in Medicinal Chemistry

Title: myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs

Volume: 7 Issue: 2

Author(s): D. J. Miller and R. K. Allemann

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Keywords: diacylglycerol, G-protein coupled receptor, Lithitum, myo-Inositol 1-phosphate, Circular dichroism, Zinc ion

Abstract: myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

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Miller J. D. and Allemann K. R., myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs, Mini-Reviews in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/138955707779802624