Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Title: Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Volume: 3 Issue: 12

Author(s): Xiaochun Wu, Yong Wu, Li Hai and Ying Bao

Affiliation:

Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery

Abstract: A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.

Cite this article as:

Wu Xiaochun, Wu Yong, Hai Li and Bao Ying, Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468004