Abstract
A crucial event in the inflammatory response is recruitment of polymorphonuclear leukocytes (PMNL) to a site of infection or injury. PMNL-epithelial interactions involve many fundamental cell processes, including adhesion, migration, secretion, phagocytosis and apoptosis. Thus, migration of PMNL across epithelial-lined organs is a primary event component of host defense. Moreover, PMNL transepithelial migration often results in disease symptoms. New insights into leukocyte-epithelial signalling mechanisms have emerged that are beginning to shed light on the role of many molecular interactions in regulating the rate of PMNL transepithelial migration. Knowledge of the basic mechanisms that control the activation of pro-inflammatory transcription factors, and how these innate immune signalling pathways lead to an activation of the adaptative immune response that maintains the chronically inflamed state, is essential for pharmacological manipulation of intestinal inflammation. This review highlights recent advances in our understanding of the different mechanisms of PMNL-epithelial cell adhesive interactions at the level of cell surface protein-protein binding events, and in intracellular signal transduction pathways that regulate the PMNL transepithelial migration. Finally, the potential modulation of these different signal pathways as possible therapeutic goals will be discussed.
Keywords: Intestinal epithelial cell, neutrophil, signalling, drugs, large bowel, Crohn'disease, ulcerative colitis, idiopathic inflammatory bowel diseases
Current Signal Transduction Therapy
Title: Regulation of Polymorphonuclear Leukocyte-Intestinal Epithelial Cell Interactions: Signalling Events and Potential Drug Targets
Volume: 2 Issue: 1
Author(s): Paul Hofman
Affiliation:
Keywords: Intestinal epithelial cell, neutrophil, signalling, drugs, large bowel, Crohn'disease, ulcerative colitis, idiopathic inflammatory bowel diseases
Abstract: A crucial event in the inflammatory response is recruitment of polymorphonuclear leukocytes (PMNL) to a site of infection or injury. PMNL-epithelial interactions involve many fundamental cell processes, including adhesion, migration, secretion, phagocytosis and apoptosis. Thus, migration of PMNL across epithelial-lined organs is a primary event component of host defense. Moreover, PMNL transepithelial migration often results in disease symptoms. New insights into leukocyte-epithelial signalling mechanisms have emerged that are beginning to shed light on the role of many molecular interactions in regulating the rate of PMNL transepithelial migration. Knowledge of the basic mechanisms that control the activation of pro-inflammatory transcription factors, and how these innate immune signalling pathways lead to an activation of the adaptative immune response that maintains the chronically inflamed state, is essential for pharmacological manipulation of intestinal inflammation. This review highlights recent advances in our understanding of the different mechanisms of PMNL-epithelial cell adhesive interactions at the level of cell surface protein-protein binding events, and in intracellular signal transduction pathways that regulate the PMNL transepithelial migration. Finally, the potential modulation of these different signal pathways as possible therapeutic goals will be discussed.
Export Options
About this article
Cite this article as:
Hofman Paul, Regulation of Polymorphonuclear Leukocyte-Intestinal Epithelial Cell Interactions: Signalling Events and Potential Drug Targets, Current Signal Transduction Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157436207779317083
DOI https://dx.doi.org/10.2174/157436207779317083 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clostridium difficile Infection: Associations with Chemotherapy, Radiation Therapy, and Targeting Therapy Treatments
Current Medicinal Chemistry The Therapeutic Potential of PhospholipaseA2 Inhibitors in Cardiovascular Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Neuropeptide Mimetics and Antagonists in the Treatment of Inflammatory Disease: Focus on VIP and PACAP
Current Topics in Medicinal Chemistry Selective Neuronal Nitric Oxide Synthase Inhibitors
Current Topics in Medicinal Chemistry Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics HIF Inhibitors: New Hope for Cancer Therapy
Letters in Drug Design & Discovery Clinical Pharmacology of Serotonin Receptor Type 3 (5-HT3) Antagonists
Current Medicinal Chemistry - Central Nervous System Agents Platelet Activating Factor/Platelet Activating Factor Receptor Pathway as a Potential Therapeutic Target in Autoimmune Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease
Current Topics in Medicinal Chemistry The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
Current Drug Metabolism Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets New Insights into HLA-G and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Involvement of Leukotriene Pathway in the Pathogenesis of Ischemia- Reperfusion Injury and Septic and Non-Septic Shock
Current Vascular Pharmacology Modulation of Eosinophil Functions by Nitric Oxide: Cyclic GMPdependent and -independent Mechanisms
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies
Current Drug Targets Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview
CNS & Neurological Disorders - Drug Targets A3 Receptor Ligands: Past, Present and Future Trends
Current Topics in Medicinal Chemistry The Molecular Basis of Class Side Effects Due to Treatment with Inhibitors of the VEGF/VEGFR Pathway
Current Clinical Pharmacology High Fat Meal Increase of IL-17 is Prevented by Ingestion of Fruit Juice Drink in Healthy Overweight Subjects
Current Pharmaceutical Design The Pivotal Role of Nitric Oxide: Effects on the Nervous and Immune Systems
Current Pharmaceutical Design