Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Mauro      Vieira De Almeida; Marcus      Vinicius de Nora Souza; Nadia      Rezende Barbosa; Frederico      Pittella Silva; Giovanni      Wilson Amarante; Sílvia      Helena Cardoso

doi:10.2174/157018007779422514

Abstract

A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds exhibited a wide range of modest in vitro activity against the tested microorganisms.

Keywords: Substituted pyridines, Amide, Antimicrobial activity, Synthesis

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Letters in Drug Design & Discovery

Title: Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Volume: 4 Issue: 2

Author(s): Mauro Vieira De Almeida, Marcus Vinicius de Nora Souza, Nadia Rezende Barbosa, Frederico Pittella Silva, Giovanni Wilson Amarante and Sílvia Helena Cardoso

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Keywords: Substituted pyridines, Amide, Antimicrobial activity, Synthesis

Abstract: A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds exhibited a wide range of modest in vitro activity against the tested microorganisms.

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Vieira De Almeida Mauro, Vinicius de Nora Souza Marcus, Rezende Barbosa Nadia, Pittella Silva Frederico, Wilson Amarante Giovanni and Helena Cardoso Sílvia, Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422514