Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

Title: Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

Volume: 4 Issue: 2

Author(s): Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber

Affiliation:

Keywords: Gene delivery, Cationic polymer, Transfection

Abstract: We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.

Cite this article as:

Chittimalla Chandrashekhar, Dalkara Deniz and Zuber Guy, Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422569

DOI https://dx.doi.org/10.2174/157018007779422569	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X