Abstract
Protein-protein interactions play a central role within numerous processes in the cell. The relevance of the processes in which this type of interactions are implicated make them responsible for many pathological situations. In the last decade protein-protein interfaces have shown their potential as new drug targets, and combinatorial chemistry has been defined as a useful tool in this line. This review gives a global vision of the actual situation of combinatorial chemistry, highlighting its applicability to high-throughput drug discovery and giving some crucial examples of its contribution to find modulators of protein-protein interactions.
Keywords: HIV protease, Integrin alpha2 I domain, Combinatorial Chemistry, Apoptosis, Rabies Virus, MMP-2
Current Topics in Medicinal Chemistry
Title: Discovery of Inhibitors of Protein-Protein Interactions from Combinatorial Libraries
Volume: 7 Issue: 1
Author(s): Maria J. Vicent, Enrique Perez-Paya and Mar Orzaez
Affiliation:
Keywords: HIV protease, Integrin alpha2 I domain, Combinatorial Chemistry, Apoptosis, Rabies Virus, MMP-2
Abstract: Protein-protein interactions play a central role within numerous processes in the cell. The relevance of the processes in which this type of interactions are implicated make them responsible for many pathological situations. In the last decade protein-protein interfaces have shown their potential as new drug targets, and combinatorial chemistry has been defined as a useful tool in this line. This review gives a global vision of the actual situation of combinatorial chemistry, highlighting its applicability to high-throughput drug discovery and giving some crucial examples of its contribution to find modulators of protein-protein interactions.
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Cite this article as:
Vicent J. Maria, Perez-Paya Enrique and Orzaez Mar, Discovery of Inhibitors of Protein-Protein Interactions from Combinatorial Libraries, Current Topics in Medicinal Chemistry 2007; 7 (1) . https://dx.doi.org/10.2174/156802607779318307
DOI https://dx.doi.org/10.2174/156802607779318307 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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