Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation

Title: Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation

Volume: 14 Issue: 1

Author(s): Xinyi Liu, Qinsheng Yuan and Huizhan Zhang

Affiliation:

Keywords: Decaprenyl diphosphate synthase, ubiquinone, site-directed mutagenesis

Abstract: Nineteen mutants of decaprenyl diphosphate synthase from Gluconobacter suboxydans were generated and their production of ubiquinones (UQs) was compared to that of the wild type protein. The accessible surface area and the polarity of amino acid around the catalytic pocket wield remarkable influences on the isoprenoid chain elongation of UQs.

Cite this article as:

Liu Xinyi, Yuan Qinsheng and Zhang Huizhan, Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117245

DOI https://dx.doi.org/10.2174/092986607779117245	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305