Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor

J.      Malm; G.   J.   Grover; M.      Farnegardh

doi:10.2174/138955707779317885

Abstract

This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.

Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective

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Mini-Reviews in Medicinal Chemistry

Title: Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor

Volume: 7 Issue: 1

Author(s): J. Malm, G. J. Grover and M. Farnegardh

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Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective

Abstract: This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.

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Malm J., Grover J. G. and Farnegardh M., Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor, Mini-Reviews in Medicinal Chemistry 2007; 7 (1) . https://dx.doi.org/10.2174/138955707779317885