Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes

Title: Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes

Volume: 4 Issue: 1

Author(s): Saibal Kumar Das, Chandrasekhar Abbineni, Krovvidi Venkata Lakshmi Narasimha Rao, Javed Iqbal, Ravi Krishna Babu and Ranjan Chakrabarti

Affiliation:

Keywords: PPAR, Diabetes, Synthesis, Ethyl 3-(4-aminophenyl)-2-ethoxypropionate, Dyslipidemia and Plasma glucose

Abstract: The design, synthesis and evaluation of several dual PPARα/γ agonists with three different heterocycles, viz. pyrazolo[4,3-d]pyrimidin-7-one, quinazolin-4-one and benzo[e][1,3]oxazine-4-one for the treatment of type 2 diabetes and associated dyslipidemia are described. Among them, compound 5cb was found to possess a potent dual PPARα/β agonist property. It significantly reversed diabetic hyperglycemia while improving overall lipid homeostasis in preclinical animal models.

Cite this article as:

Kumar Das Saibal, Abbineni Chandrasekhar, Venkata Lakshmi Narasimha Rao Krovvidi, Iqbal Javed, Krishna Babu Ravi and Chakrabarti Ranjan, Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes, Letters in Drug Design & Discovery 2007; 4 (1) . https://dx.doi.org/10.2174/157018007778992883