The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains

Title: The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains

Volume: 13 Issue: 7

Author(s): Xing Sheng Wang, Dong Liang Wang, Jing Zhao, Mei Hua Qu, Xiao Hong Zhou, Hai Jin He and Rong Qiao He

Affiliation:

Keywords: Neuronal tau, RNA, non-sequence-specific RNA-binding, electrostatic interaction, proline rich domain, microtubule binding domain

Abstract: Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA nonsequence- specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

Cite this article as:

Wang Xing Sheng, Wang Dong Liang, Zhao Jing, Qu Mei Hua, Zhou Xiao Hong, He Hai Jin and He Rong Qiao, The Proline-Rich Domain and the Microtubule Binding Domain of Protein Tau Acting as RNA Binding Domains, Protein & Peptide Letters 2006; 13 (7) . https://dx.doi.org/10.2174/092986606777790566