Synthesis of Oxepin- and Oxocin- Annulated Pyrimidine Derivatives by Claisen Rearrangement and Ring Closing Metathesis/Ring Closing Enyne Metathesis (SUPORTING DATA)

Title: Synthesis of Oxepin- and Oxocin- Annulated Pyrimidine Derivatives by Claisen Rearrangement and Ring Closing Metathesis/Ring Closing Enyne Metathesis (SUPORTING DATA)

Volume: 3 Issue: 11

Author(s): Krishna C. Majumdar, Pradip K. Maji, Habibur Rahaman and Brindaban Roy

Affiliation:

Keywords: 1,3-dimethyl-5-hydroxyuracil, Claisen rearrangement, ring closing metathesis, enyne metathesis, oxepin, oxocin

Abstract: A novel procedure is described for the formation of methyl and vinyl substituted oxacycle fused uracil derivatives. Ring closing metathesis and enyne metathesis of dienes and enynes respectively proceeded smoothly under nitrogen atmosphere at room temperature in the presence of well defined catalyst (first generation Grubbs catalyst) to afford the substituted oxepin derivatives in good yields. The substrates were prepared by the Claisen rearrangement and subsequent alkylation of the rearranged products.

Cite this article as:

Majumdar C. Krishna, Maji K. Pradip, Rahaman Habibur and Roy Brindaban, Synthesis of Oxepin- and Oxocin- Annulated Pyrimidine Derivatives by Claisen Rearrangement and Ring Closing Metathesis/Ring Closing Enyne Metathesis (SUPORTING DATA), Letters in Organic Chemistry 2006; 3 (11) . https://dx.doi.org/10.2174/157017806779117094