Carbohydrate-Based Scaffolds in Drug Discovery

Bernd      Becker; Glenn   C.   Condie; Giang      Thanh Le; Wim      Meutermans

doi:10.2174/138955706778993003

Abstract

Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics

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Mini-Reviews in Medicinal Chemistry

Title: Carbohydrate-Based Scaffolds in Drug Discovery

Volume: 6 Issue: 12

Author(s): Bernd Becker, Glenn C. Condie, Giang Thanh Le and Wim Meutermans

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Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics

Abstract: Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

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Becker Bernd, Condie C. Glenn, Thanh Le Giang and Meutermans Wim, Carbohydrate-Based Scaffolds in Drug Discovery, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993003