Abstract
Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.
Keywords: neuromuscular pain, hypothalamic-pituitary-adrenal (HPA) axis, non-inflammatory process, thyrotropin, lymphocyte proliferation responses, Chronic Fatigue Syndrome, rheumatology
Current Pharmaceutical Design
Title: Is There a Role for Cytokine Based Therapies in Fibromyalgia
Volume: 12 Issue: 1
Author(s): Daniel J. Wallace
Affiliation:
Keywords: neuromuscular pain, hypothalamic-pituitary-adrenal (HPA) axis, non-inflammatory process, thyrotropin, lymphocyte proliferation responses, Chronic Fatigue Syndrome, rheumatology
Abstract: Cytokines are glycoproteins that serve as chemical messengers between cells. They assist in the regulation of cell growth and repair and also have immune modulating properties. Cytokines play a role in diverse clinical processes and phenomena such as fatigue, fever, sleep, pain, stress and aching. A review of the fibromyalgia literature and related studies suggest that IL-1, IL-6 and IL-8 are dysregulated in the syndrome. Therapies directed against these cytokines may be of potential importance in the management of fibromyalgia.
Export Options
About this article
Cite this article as:
Wallace J. Daniel, Is There a Role for Cytokine Based Therapies in Fibromyalgia, Current Pharmaceutical Design 2006; 12 (1) . https://dx.doi.org/10.2174/138161206775193208
DOI https://dx.doi.org/10.2174/138161206775193208 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
1,3,4-Thiadiazole Based Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Role of EGFR Monoclonal Antibodies in the Management of Non–small Cell Lung Cancer
Current Cancer Drug Targets Nutrigenomics: Advances, Opportunities and Challenges in Understanding the Nutrient-Gene Interactions
Current Nutrition & Food Science Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer
Current Gene Therapy Matrix Metalloproteinases: New Routes to the Use of MT1-MMP As A Therapeutic Target in Angiogenesis-Related Disease
Current Pharmaceutical Design Potential for Predicting Toxicity and Response of Fluoropyrimidines in Patients
Current Drug Targets Genetic Approaches for Antigen-Selective Cell Therapy
Current Gene Therapy Association of ATG7 Polymorphisms and Clear Cell Renal Cell Carcinoma Risk
Current Molecular Medicine Small Molecule Aurora Kinases Inhibitors
Current Medicinal Chemistry Understanding Epithelial-Mesenchymal Transition may Reveal Novel Therapeutic Targets for Oral Squamous Cell Carcinoma
Current Cancer Therapy Reviews Perspectives in Biomolecular Therapeutic Intervention in Cancer: From the Early to the New Strategies With Type I Interferons
Current Medicinal Chemistry Translational Multimodality Neuroimaging
Current Drug Targets Molecular Targets of FTY720 (Fingolimod)
Current Molecular Medicine Ideal and Reality: Barricade in the Delivery of Small Interfering RNA for Cancer Therapy
Current Pharmaceutical Biotechnology Radiopharmaceuticals in Tumor Hypoxia Imaging: A Review Focused on Medicinal Chemistry Aspects
Anti-Cancer Agents in Medicinal Chemistry Monoclonal Antibodies in Clinical Oncology
Anti-Cancer Agents in Medicinal Chemistry Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy
Current Topics in Medicinal Chemistry The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure
Current Hypertension Reviews Environmentally Sensitive Paramagnetic and Diamagnetic Contrast Agents for Nuclear Magnetic Resonance Imaging and Spectroscopy
Current Topics in Medicinal Chemistry Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design