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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)

Author(s): Caroline P. Owen, Chirag H. Patel, Sachin Dhanani and Sabbir Ahmed

Volume 3, Issue 10, 2006

Page: [761 - 765] Pages: 5

DOI: 10.2174/157018006778631857

Price: $65

Abstract

We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.

Keywords: 17α-Hydroxylase, 17, 20-Lyase, P45017α, Synthesis, Evaluation, Triazole

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