Abstract
We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.
Keywords: 17α-Hydroxylase, 17, 20-Lyase, P45017α, Synthesis, Evaluation, Triazole
Letters in Drug Design & Discovery
Title: Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)
Volume: 3 Issue: 10
Author(s): Caroline P. Owen, Chirag H. Patel, Sachin Dhanani and Sabbir Ahmed
Affiliation:
Keywords: 17α-Hydroxylase, 17, 20-Lyase, P45017α, Synthesis, Evaluation, Triazole
Abstract: We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.
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P. Owen Caroline, H. Patel Chirag, Dhanani Sachin and Ahmed Sabbir, Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α), Letters in Drug Design & Discovery 2006; 3 (10) . https://dx.doi.org/10.2174/157018006778631857
DOI https://dx.doi.org/10.2174/157018006778631857 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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