Synthesis and Biological Activity of Akt/PI3K Inhibitors

Title: Synthesis and Biological Activity of Akt/PI3K Inhibitors

Volume: 6 Issue: 10

Author(s): C. Redaelli, F. Granucci, L. De Gioia and L. Cipolla

Affiliation:

Keywords: Kinases, Akt, PI3K, cancer, kinase inhibitors, allosteric inhibitors, phosphatidylinositol, phosphatidylinositol analogues

Abstract: Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.

Cite this article as:

Redaelli C., Granucci F., De Gioia L. and Cipolla L., Synthesis and Biological Activity of Akt/PI3K Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560139