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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Cytotoxicity of Native Sponges and Plants from the Colombian Caribbean Coast Against “Crown Gall” Tumors Induced by Agrobacterium tumefaciens

Author(s): Fredyc Diaz, Ricardo Gaitan, Delfina Urbina, Ketty Mendoza, Marta Puello, Gregorio Torres and Eduardo de Avila

Volume 3, Issue 9, 2006

Page: [640 - 644] Pages: 5

DOI: 10.2174/157018006778341129

Price: $65

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Abstract

Agrobacterium tumefaciens is a Gram-negative rod able to induce crown-gall-like tumors in the potato discs. The cytotoxicity of extracts from Tabebuia and Xetospongia spp. was evaluated using this model. Two out of the six extracts tested (dichloromethane- and partial methanol-soluble extracts of Xetospongias spp.) showed the highest biological activity.

Keywords: Tabebuia spp., Xetospongias spp., Agrobacterium tumefaciens, Ti plasmidum, Solanum tuberosum and, cytotoxicity


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