A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids

Ferenc      Fulop; Istvan      Szatmari; Lorand      Kiss

doi:10.2174/157017806777828501

Abstract

Simple and efficient methods have been developed for the synthesis of orthogonally protected 2,5- diaminocyclohexanecarboxylic acid diastereomers via the stereocontrolled transformation of 2-benzyloxycarbonylamino-4-cyclohexenecarboxylic acid to its iodolactone or epoxide.

Keywords: orthogonal protection, β-peptides, β-amino acids, Diaminocarboxylic acids

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Letters in Organic Chemistry

Title: A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids

Volume: 3 Issue: 6

Author(s): Ferenc Fulop, Istvan Szatmari and Lorand Kiss

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Keywords: orthogonal protection, β-peptides, β-amino acids, Diaminocarboxylic acids

Abstract: Simple and efficient methods have been developed for the synthesis of orthogonally protected 2,5- diaminocyclohexanecarboxylic acid diastereomers via the stereocontrolled transformation of 2-benzyloxycarbonylamino-4-cyclohexenecarboxylic acid to its iodolactone or epoxide.

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Fulop Ferenc, Szatmari Istvan and Kiss Lorand, A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids, Letters in Organic Chemistry 2006; 3 (6) . https://dx.doi.org/10.2174/157017806777828501